Direct oral anticoagulants showed comparable quality of life to warfarin, higher treatment satisfaction (P=0.004), and lower hospitalization rates (3.0% vs 15.6%, P=0.002).
Cross-Sectional (n=208)
No
Does DOAC improve quality of life and treatment satisfaction compared to warfarin in patients with NVAF or VTE?
DOACs offer comparable quality of life but higher treatment satisfaction and lower hospitalization rates compared to warfarin in patients with NVAF or VTE.
p-value: p=0.083 (physical QOL), 0.665 (mental QOL), 0.004 (treatment satisfaction)
Introduction and aim: Patient quality of life (QOL) while on long-term oral anticoagulant therapy has been receiving greater attention in recent years due to the increase in life expectancy brought about by advances in medical care. This study aimed to compare the QOL, treatment satisfaction, hospitalization and bleeding rate in patients on long-term warfarin versus direct oral anticoagulants (DOAC). Methods: This was a cross-sectional study of patients with non-valvular atrial fibrillation (NVAF) or venous thromboembolism (VTE) on long-term anticoagulant therapy attending the cardiology clinic and anticoagulation clinic of the University Malaya Medical Centre from July 1, 2016, to June 30, 2018. Patient QOL was assessed by using the Short Form 12 Health Survey (SF12), while treatment satisfaction was assessed by using the Perception of Anticoagulation Treatment Questionnaire 2 (PACT-Q2). Results: A total of 208 patients were recruited; 52.4% received warfarin and 47.6% received DOAC. There was no significant difference in QOL between warfarin and DOAC based on SF12 (physical QOL, P =0.083; mental QOL, P =0.665). Nevertheless, patients in the DOAC group were significantly more satisfied with their treatment compared to the warfarin group based on PACT-Q2 ( P =0.004). The hospitalisation rate was significantly higher in the warfarin group than the DOAC group (15.6% versus 3.0%, P =0.002). Clinically relevant minor bleeds and severe bleeding events were non-significantly higher in the warfarin group than the DOAC group (66.7% versus 40.0%, P =0.069). Conclusion: Compared to warfarin, treatment of NVAF and VTE with DOAC showed comparable QOL, higher treatment satisfaction, lesser hospitalization, and a non-significant trend toward fewer bleeding episodes. Keywords: quality of life, treatment satisfaction, convenience, warfarin, direct oral anticoagulants
Ng et al. (Thu,) conducted a cross-sectional in Non-valvular atrial fibrillation (NVAF) or venous thromboembolism (VTE) (n=208). Direct oral anticoagulants (DOAC) vs. Warfarin was evaluated on Quality of life (SF12) and treatment satisfaction (PACT-Q2) (p=0.083 (physical QOL), 0.665 (mental QOL), 0.004 (treatment satisfaction)). Direct oral anticoagulants showed comparable quality of life to warfarin, higher treatment satisfaction (P=0.004), and lower hospitalization rates (3.0% vs 15.6%, P=0.002).