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September 29, 2011Neurology InternationalOpen Access

ACEI, ARB, CCB, and thiazide diuretics each reduce the risk of stroke compared with placebo or no treatment, though clinical trials are needed to confirm the efficacy of fixed-dose combinations in primary stroke prevention.

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Why the study?

Does antihypertensive treatment reduce the risk of stroke in patients with hypertension?

Population

Patients with hypertension, including the general population, diabetics, and subjects with high…

Comparison

Antihypertensive agents and fixed-dose… vs Placebo or no treatment

Design

Review

Authors

RRRoberta RavenniJJJoe F. JabreECEdoardo Casiglia

Discussion

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Member takes

Overview

Supports these antihypertensives for stroke prevention in hypertension; leaves open fixed-dose combination efficacy pending dedicated trials.

Structured PICO

Does antihypertensive treatment reduce the risk of stroke in patients with hypertension?

P
Population
Patients with hypertension, including the general population, diabetics, and subjects with high cardiovascular risk and renal disease
I
Intervention
Antihypertensive agents (angiotensin-converting enzyme inhibitors [ACEI], angiotensin II receptor blockers [ARB], dihydropyridine calcium channel blockers [CCB], thiazide diuretics) and fixed-dose combinations
C
Comparator
Placebo or no treatment
O
Outcome
Risk of strokehard clinical

Antihypertensive therapy with ACEI, ARB, CCB, or thiazide diuretics effectively reduces stroke risk, and fixed-dose combinations may help achieve guideline-recommended blood pressure targets for primary stroke prevention.

Cite This Study

Ravenni et al. (2011) studied this question.

synapsesocial.com/papers/6a224bf853130ceb007fc9e9https://doi.org/10.4081/ni.2011.e12
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Primary and secondary prevention of stroke by antihypertensive drug treatment2004 · 10 citations
  2. 2Blood Pressure Control and Primary Prevention of Stroke: Summary of the Recent Clinical Trial Data and Meta-Analyses2013 · 120 citations
  3. 3Blood Pressure Lowering for the Primary and Secondary Prevention of Stroke: Treatment of Hypertension Reduces the Risk of Stroke1999 · 14 citations
  4. 4Blood Pressure and Prevention of Stroke2017 · 3 citations
  5. 5Blood Pressure as a Therapeutic Target in Stroke2009 · 5 citations