Key result
In vitro translation and mutagenesis confirmed that the N-terminal region of the equine arteritis virus replicase contains a papainlike cysteine protease domain directing autoproteolytic cleavage.
The study confirms the presence of a papainlike cysteine protease domain in the EAV replicase and identifies its cleavage site and catalytic residues.
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No immediate clinical implications; leaves open targeted antiviral strategies against arteriviruses.
Snijder et al. (1992) studied Equine arteritis virus (EAV). In vitro translation and mutagenesis was evaluated on Identification and characterization of the papainlike cysteine protease (PCP) domain. In vitro translation and mutagenesis confirmed that the N-terminal region of the equine arteritis virus replicase contains a papainlike cysteine protease domain directing autoproteolytic cleavage.
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