July 1, 1995Journal of VirologyOpen Access

Processing and evolution of the N-terminal region of the arterivirus replicase ORF1a protein: identification of two papainlike cysteine proteases

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Structured PICO

Population

Arteriviruses (porcine reproductive and respiratory syndrome virus, lactate dehydrogenase-elevating virus, equine arteritis virus) replicase ORF1a proteins

Intervention

In vitro translation, site-directed mutagenesis, and sequence comparison

Outcome

Identification and characterization of papainlike cysteine protease (PCP) domains and their processing products

Identifies two papainlike cysteine proteases in the replicase of specific arteriviruses and elucidates their cleavage functions.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Extends arterivirus replicase models; leaves open whether these domains are viable antiviral targets.

Cite This Study

Boon et al. (1995) studied this question.

synapsesocial.com/papers/6a73bb94c973d0bd5a69ef14 https://doi.org/10.1128/jvi.69.7.4500-4505.1995

View Full Paper

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Processing and evolution of the N-terminal region of the arterivirus replicase ORF1a protein: identification of two papainlike cysteine proteases

Structured PICO

Discussion

Implication

Cite This Study

Processing and evolution of the N-terminal region of the arterivirus replicase ORF1a protein: identification of two papainlike cysteine proteases

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider