Key result
Automated 10-second Global Electrical Heterogeneity ECG measurements demonstrated substantial reproducibility with Lin's concordance coefficients >0.98 and precision >99.9%.
Why the study?
Global electrical heterogeneity predicts adverse clinical outcomes, but the reproducibility of its measurements on 10-second routine clinical ECG is unknown.
Are automated Global Electrical Heterogeneity (GEH) measurements reproducible across different 10-second ECG segments in incident hemodialysis patients?
Cohort (n=253)
Are automated Global Electrical Heterogeneity (GEH) measurements reproducible across different 10-second ECG segments in incident hemodialysis patients?
Effect estimate: Lin's concordance coefficient 0.981 (95% CI 0.976-0.985)
Automated 10-second ECG measurements of Global Electrical Heterogeneity are highly reproducible and precise, supporting their potential implementation in routine clinical practice for risk stratification.
Reproducible automated GEH measurements support consistent research use in hemodialysis; leaves open clinical adoption pending outcome studies.
BACKGROUND: Global electrical heterogeneity (GEH) is a useful predictor of adverse clinical outcomes. However, reproducibility of GEH measurements on 10-second routine clinical ECG is unknown. METHODS: ). Bland-Altman analysis was used to calculate agreement. RESULTS: were in substantial agreement with each other. CONCLUSION: Reproducibility of a 10-second automated GEH ECG measurements was substantial, and precision was perfect.
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Alday et al. (2018) conducted a cohort in End-stage renal disease on incident hemodialysis (n=253). 10-second automated GEH ECG measurements vs. Second random 10-second ECG segment was evaluated on Reproducibility of spatial QRS-T angle (Area QRS-T angle) (Lin's concordance coefficient 0.981, 95% CI 0.976-0.985). Automated 10-second Global Electrical Heterogeneity ECG measurements demonstrated substantial reproducibility with Lin's concordance coefficients >0.98 and precision >99.9%.
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