Key result
Global electrical heterogeneity is independently associated with sudden cardiac death after adjustment for demographics, cardiovascular disease, and known risk factors.
Why the study?
This review summarizes recent findings and discusses the clinical significance of vectorcardiographic global electrical heterogeneity.
Global electrical heterogeneity (GEH) measured via vectorcardiography serves as an independent electrophysiological substrate and predictor for sudden cardiac death.
This review summarizes recent findings and discusses a clinical significance of a vectorcardiographic (VCG) Global electrical heterogeneity (GEH). GEH concept is based on the concept of the spatial ventricular gradient (SVG), which is a global measure of the dispersion of total recovery time. We quantify GEH by measuring five features of the SVG vector (SVG magnitude, direction (azimuth and elevation), a scalar value, and spatial QRS-T angle) on orthogonal XYZ ECG. In analysis of more than 20,000 adults we showed that GEH is independently associated with sudden cardiac death (SCD) after adjustment for demographics, cardiovascular disease (time-updated incident non-fatal cardiovascular events [coronary heart disease, heart failure, stroke, atrial fibrillation, use of beta-blockers], and known risk factors [cholesterol, triglycerides, physical activity index, smoking, diabetes, obesity, hypertension, anti-hypertensive medications, creatinine, alcohol intake, left ventricular ejection fraction, and time-updated ECG metrics (heart rate, QTc, QRS duration, ECG-left ventricular hypertrophy, bundle branch block or interventricular conduction delay)]. This finding suggests that GEH represents an independent electrophysiological substrate of SCD.
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Larisa G. Tereshchenko (2018) conducted a review in Sudden cardiac death risk (n=20,000). Global electrical heterogeneity (GEH) was evaluated on Sudden cardiac death (SCD). Global electrical heterogeneity is independently associated with sudden cardiac death after adjustment for demographics, cardiovascular disease, and known risk factors.
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