Key result
Replacing 4 mM ATP with 10 mM CTP decreased maximum shortening velocity in rabbit psoas (3.26 to 1.87 ML/s) and rat soleus fibers (1.94 to 0.90 ML/s), while peak power remained unaffected.
Population
Single muscle fibers from fast rabbit psoas and slow rat soleus muscles
Comparison
CTP as the nucleotide substrate vs ATP as the nucleotide substrate
Design
Preclinical
Authors
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May guide nucleotide studies in muscle models; leaves open translation to human cardiac performance.
Absolute Event Rate: 1.87% vs 3.26%
Peak power output in rabbit psoas and rat soleus single muscle fibers is maintained when CTP replaces ATP, despite a decrease in maximum shortening velocity, due to a decrease in the curvature of the force-velocity relationship.
Wahr et al. (1998) studied Striated muscle contraction. MgCTP vs. MgATP (0.2 mM or 4 mM) was evaluated on Maximum shortening velocity (Vmax) in psoas fibers (muscle length/s). Replacing 4 mM ATP with 10 mM CTP decreased maximum shortening velocity in rabbit psoas (3.26 to 1.87 ML/s) and rat soleus fibers (1.94 to 0.90 ML/s), while peak power remained unaffected.
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