Key result
CTP was an effective substrate for rabbit psoas fiber contraction with mechanical parameters 65-100% of those obtained with ATP, whereas GTP and aza-ATP were poor substrates.
Population
Chemically skinned rabbit psoas fibers
Comparison
Nucleotides GTP, CTP, and 1-N6-etheno-2-aza-ATP vs ATP
Design
Preclinical
Authors
Loading...
Animal data only; extends nucleotide specificity research in contraction but leaves open translation to other models or systems.
In chemically skinned rabbit psoas fibers, CTP effectively supports contraction similarly to ATP, whereas GTP and aza-ATP are poor substrates.
Pate et al. (1993) studied this question. GTP, CTP, and aza-ATP vs. ATP was evaluated on isometric tension, isometric GTPase rate, and maximum shortening velocity (Vmax). CTP was an effective substrate for rabbit psoas fiber contraction with mechanical parameters 65-100% of those obtained with ATP, whereas GTP and aza-ATP were poor substrates.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: