December 1, 1992Proceedings of the National Academy of SciencesOpen Access

Effect of Ca2+ on weak cross-bridge interaction with actin in the presence of adenosine 5'-gamma-thiotriphosphate).

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Population

Single skinned fibers of the rabbit psoas muscle

Comparison

Raising Ca2+ concentration up to pCa 4.5 in the… vs Lower Ca2+ concentrations

Design

Preclinical

Authors

TKTerry KraftLeibniz University Hannover LYLinda Chia‐Hui YuNational Taiwan University HKHans KuhnUniversity of Stuttgart

Discussion

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Implication

Does not support clinical changes in Ca2+ management; leaves open translation to human cardiac cross-bridge kinetics.

Structured PICO

Population

Single skinned fibers of the rabbit psoas muscle

Intervention

Raising Ca2+ concentration up to pCa 4.5 in the presence of adenosine 5'-[gamma-thio]triphosphate (ATP[gamma S])

Comparator

Lower Ca2+ concentrations

Outcome

Stiffness and equatorial x-ray diffraction patterns (actin affinity, rate constants for cross-bridge dissociation and reassociation, nucleotide affinity)surrogate

In rabbit psoas muscle fibers, high Ca2+ concentrations reduce the rate constants for cross-bridge dissociation and reassociation by about 2 orders of magnitude in the presence of ATP[gamma S].

Cite This Study

Kraft et al. (1992) studied this question.

synapsesocial.com/papers/6a20a8369ca8a48788f36f1a https://doi.org/10.1073/pnas.89.23.11362

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Effect of Ca2+ on weak cross-bridge interaction with actin in the presence of adenosine 5'-gamma-thiotriphosphate).

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of Ca2+ on weak cross-bridge interaction with actin in the presence of adenosine 5'-gamma-thiotriphosphate).

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider