Why the study?
Does fluvastatin improve skin microvascular responses in patients with hypercholesterolaemia and peripheral arterial obstructive disease?
Population
Patients with hypercholesterolaemia and peripheral arterial obstructive disease (PAOD)
Comparison
Fluvastatin 40 mg/day for 24 weeks vs Baseline and control subjects
Design
Cohort, unrandomized, open design
Follow-up
24 weeks
Authors
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Associated microvascular improvement in hypercholesterolemic PAOD; hypothesis-generating and leaves open clinical outcome impact pending RCTs.
Does fluvastatin improve skin microvascular responses in patients with hypercholesterolaemia and peripheral arterial obstructive disease?
Cholesterol-lowering with fluvastatin significantly improves endothelium-independent vascular responses in the skin microvessels of patients with hypercholesterolaemia and PAOD.
Khan et al. (1999) studied this question.
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