July 21, 2003Diabetic Medicine
The renin–angiotensin system and the long‐term complications of diabetes: pathophysiological and therapeutic considerations
Why the study?
Does blockade of the renin-angiotensin system provide protection from the long-term complications of diabetes beyond that due to blood pressure reduction alone?
Population
Patients with diabetes at risk for long-term micro- and macrovascular complications
Comparison
Blockade of the renin-angiotensin system vs Blood pressure reduction alone
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
Supports ACEi/ARB use to mitigate diabetic complications; leaves open whether effects exceed BP lowering alone.
Structured PICO
Does blockade of the renin-angiotensin system provide protection from the long-term complications of diabetes beyond that due to blood pressure reduction alone?
P
Population
Patients with diabetes at risk for long-term micro- and macrovascular complications
I
Intervention
Blockade of the renin-angiotensin system (ACE inhibition and angiotensin receptor blockade)
C
Comparator
Blood pressure reduction alone
O
Outcome
Development and progression of diabetic nephropathy, cardiovascular disease, and retinopathy
Blockade of the renin-angiotensin system with ACE inhibitors or ARBs provides protection against diabetic nephropathy and cardiovascular disease beyond blood pressure reduction alone.
Cite This Study
Gilbert et al. (2003) studied this question.