Key result
QT interval prolongation during bradycardia, rather than the severity of bradycardia per se, correlates with the risk of torsades de pointes during atrioventricular block.
QT interval prolongation during bradycardia, rather than the severity of bradycardia itself, correlates with the risk of torsades de pointes during atrioventricular block.
Bradycardia-induced long QT syndrome (LQTS) caused by complete atrioventricular (AV) block is one of the causes of QT-related arrhythmias (torsades de pointes) most frequently encountered in clinical practice. 2 Kurita T. Ohe T. Marui N. et al. Bradycardia-induced abnormal QT prolongation in patients with complete atrioventricular block with torsades de pointes. Am J Cardiol. 1992; 69: 628-633 Abstract Full Text PDF PubMed Scopus (116) Google Scholar , 3 Topilski I. Rogowski O. Rosso R. et al. The morphology of the QT interval predicts torsade de pointes during acquired bradyarrhythmias. J Am Coll Cardiol. 2007; 49: 320-328 Crossref PubMed Scopus (192) Google Scholar , 4 Chorin E. Hochstadt A. Viskin S. et al. Female gender as independent risk factor of torsades de pointes during acquired atrioventricular block. Heart Rhythm. 2017; 14: 90-95 Abstract Full Text Full Text PDF PubMed Scopus (26) Google Scholar Although QT prolongation is a normal response to heart rate slowing, some patients prolong their QT interval more than others during severe bradycardia. 2 Kurita T. Ohe T. Marui N. et al. Bradycardia-induced abnormal QT prolongation in patients with complete atrioventricular block with torsades de pointes. Am J Cardiol. 1992; 69: 628-633 Abstract Full Text PDF PubMed Scopus (116) Google Scholar In fact, QT interval prolongation during bradycardia, rather than the severity of bradycardia per se, correlates with the risk of torsades de pointes during AV block. 2 Kurita T. Ohe T. Marui N. et al. Bradycardia-induced abnormal QT prolongation in patients with complete atrioventricular block with torsades de pointes. Am J Cardiol. 1992; 69: 628-633 Abstract Full Text PDF PubMed Scopus (116) Google Scholar ,3 Topilski I. Rogowski O. Rosso R. et al. The morphology of the QT interval predicts torsade de pointes during acquired bradyarrhythmias. J Am Coll Cardiol. 2007; 49: 320-328 Crossref PubMed Scopus (192) Google Scholar
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Barashi et al. (2023) conducted an editorial in Bradycardia-induced long QT syndrome (LQTS) caused by complete atrioventricular block. Severe bradycardia and QT prolongation was evaluated on Torsades de pointes. QT interval prolongation during bradycardia, rather than the severity of bradycardia per se, correlates with the risk of torsades de pointes during atrioventricular block.
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