Key result
Drugs increasing ventricular repolarization dispersion prolong the QT interval and heighten risk of malignant ventricular arrhythmias.
Why the study?
Prolongation of the QT interval can arise from different mechanisms including bradycardia and sympathetic imbalances, and drugs increasing repolarization dispersion may raise arrhythmia risk.
Design
Review
Loading...
Increased repolarization heterogeneity may promote torsades in prolonged QT; leaves open its role in risk stratification.
Drugs that increase the dispersion of the ventricular repolarization process can prolong the QT interval and precipitate malignant ventricular arrhythmias such as torsades de pointes.
A 1993 study conducted a review in Prolonged QT syndrome and ventricular tachyarrhythmias. Drugs that increase dispersion of repolarization (e.g., class IA and class III antiarrhythmic agents) was evaluated on QT interval prolongation and potential for arrhythmias. Drugs that increase the dispersion of the ventricular repolarization process may prolong the QT interval and raise the potential for malignant ventricular arrhythmias, including torsades de pointes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: