Heterogeneity of cellular repolarization in LQTS: the role of M cells
Population
Patients with congenital or acquired long QT syndrome (LQTS) and ventricular myocardium models
Design
Review
Authors
Discussion
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Implication
Challenges QT-centric risk stratification in long QT syndrome; supports investigation of repolarization dispersion as therapeutic target.
Structured PICO
P
Population
Patients with congenital or acquired long QT syndrome (LQTS) and ventricular myocardium models
This review highlights that transmural dispersion of repolarization, driven by M cells, rather than QT prolongation alone, is the primary mechanism underlying torsade de pointes in long QT syndrome.
Cite This Study
Charles Antzelevitch (2001) studied this question.