Candidate Screening for Heart Failure With Preserved Ejection Fraction Clinic by Fib-4 Index From Subclinical Subjects

Figures

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  Figure 1. Kaplan–Meier analysis of HFpEF risk for the clinical outcomes. Kaplan–Meier analysis for clinical events (composite endpoint of all-cause mortality and hospitalization due to heart failure) and MACE (composite endpoint of cardiovascular mortality, occurrence of acute myocardial infarction and stroke, hospitalization due to heart failure, and ischemic cardiovascular events) showed that the groups with low and intermediate HFpEF risk had fewer events than the high-risk group (log-rank P = .002 and P < .001, respectively). MACE, major adverse cardiovascular events; HFpEF, heart failure with preserved ejection fraction.

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  Figure 2. Correlation between the Fib-4 index and HFA-PEFF Score. (A): A significant correlation was found between the Fib-4 index (log scale) and hierarchical modeling of the HFA-PEFF score (rs = 0.526, P < .001) using the Spearman’s rank correlation test. Error bars indicate 95% CI. (B): The Fib-4 index (log scale) correlated with parameters for calculating the HFA-PEFF score, including septal E/e’ (r = 0.293, P < .001), LVMI (r = 0.266, P < .001), RWT (r = 0.236, P < .001), and BNP (log scale) (r = 0.446, P < .001), and negatively correlated with septal e’ (r = 0.475, P < .001) using Pearson's correlation coefficient. BNP, B-type natriuretic peptide; LV, left ventricle; LVMI, LV mass index; RWT, relative wall thickness; CI, confidence interval.

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  Figure 3. Kaplan–Meier analysis of the Fib-4 Index for the clinical outcomes. Kaplan–Meier analysis for clinical events (composite endpoint of all-cause mortality and hospitalization due to heart failure) and MACE (composite endpoint of cardiovascular mortality, occurrence of acute myocardial infarction and stroke, hospitalization due to heart failure, and ischemic cardiovascular events) showed that groups with low and intermediate Fib-4 index had fewer events than the high score group (both P < .001, log-rank). MACE, major adverse cardiovascular events.