Population
Foot-and-mouth disease virus (FMDV) full-length infectious clone and susceptible cells
Comparison
Deletion of the 3' noncoding region or exchange… vs Intact FMDV 3' NCR (wild-type)
Design
Preclinical
Authors
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FMDV 3' NCR sequences are replication-essential and virus-specific; leaves open targeted antiviral strategies pending in vivo validation.
The 3' noncoding region of foot-and-mouth disease virus is essential for viral replication and cannot be functionally replaced by the equivalent region from swine vesicular disease virus.
Sáiz et al. (2001) studied this question.
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