Key result
HCV RNA containing the 3'-UTR X region was translated three- to fivefold more efficiently than corresponding RNAs without this region, an enhancement that occurs only in cis.
Population
HCV RNAs differing in their 3'-UTRs
Comparison
Presence of the X region at the 3'-UTR vs Corresponding RNAs without the X region
Design
Preclinical
Authors
Loading...
HCV X-PTB-IRES linkage may enhance translation; leaves open antiviral targeting.
Effect estimate: three- to fivefold more
The highly conserved 3' end (X region) of HCV RNA enhances translation in cis, providing a potential target for antiviral agents.
Ito et al. (1998) studied Hepatitis C virus (HCV). HCV RNA containing the X region at the 3'-UTR vs. Corresponding RNAs without the X region was evaluated on Translation efficiency (three- to fivefold more). HCV RNA containing the 3'-UTR X region was translated three- to fivefold more efficiently than corresponding RNAs without this region, an enhancement that occurs only in cis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: