Key result
A multifactorial intervention improved blood pressure control at 6 months (OR for uncontrolled systolic BP 0.62; 95% CI 0.50-0.78) but did not reduce long-term cardiovascular events.
Why the study?
Does a multifactorial intervention improve blood pressure control in patients ≥ 50 years of age with uncontrolled hypertension and high cardiovascular risk?
Population
877 patients ≥ 50 years of age with uncontrolled hypertension and an estimated 10-year cardiovascular risk…
Comparison
Multifactorial intervention consisting of… vs Control group (standard care)
Design
RCT, cluster-randomized
Follow-up
mean 39 months
Authors
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Short-term BP control gains fail to reduce CV events; challenges surrogate endpoint reliance in hypertension trials.
RCT (n=877)
cluster-randomized
Yes
Does a multifactorial intervention improve blood pressure control in patients ≥ 50 years of age with uncontrolled hypertension and high cardiovascular risk?
Odds Ratio: 0.62 (95% CI 0.5–0.78)
A multifactorial intervention improved adherence and blood pressure control at 6 months but did not reduce long-term cardiovascular events.
Pladevall et al. (2010) conducted an RCT in uncontrolled hypertension (n=877). Multifactorial intervention vs. Control was evaluated on blood pressure control at 6 months (OR 0.62, 95% CI 0.50 to 0.78). A multifactorial intervention improved blood pressure control at 6 months (OR for uncontrolled systolic BP 0.62; 95% CI 0.50-0.78) but did not reduce long-term cardiovascular events.
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