Key result
Cooperative mechanism 3 produced steep force-Ca2+ relations and twitches where latency to peak is independent of the magnitude of force, matching experimental data.
Computational modeling suggests that end-to-end interactions between adjacent troponin and tropomyosin best explain the experimentally observed length-dependent steady-state and dynamic responses in cardiac myofilaments.
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End-to-end troponin-tropomyosin cooperativity may explain cardiac length dependence; extends myofilament models but leaves open in vivo validation.
Rice et al. (1999) studied Cardiac muscle force generation. Computational models of cooperative mechanisms vs. Experimental data from the literature was evaluated on Length-dependent steady-state and dynamic responses. Cooperative mechanism 3 produced steep force-Ca2+ relations and twitches where latency to peak is independent of the magnitude of force, matching experimental data.
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