Key result
A 60-year-old hypertensive woman developed a right-sided thalamic haemorrhage 5 days after starting dual antiplatelet therapy for a lacunar infarct, despite optimally controlled hypertension.
Why the study?
Does dual antiplatelet therapy (aspirin and clopidogrel) cause recurrent intracerebral haemorrhage in a patient with a history of hypertensive intracerebral haemorrhages who sustains a new ischaemic event?
Case Report (n=1)
Does dual antiplatelet therapy (aspirin and clopidogrel) cause recurrent intracerebral haemorrhage in a patient with a history of hypertensive intracerebral haemorrhages who sustains a new ischaemic event?
Answers are grounded in this paper and cite their sources.
Dual antiplatelet therapy for a new ischemic event in a patient with a history of hypertensive intracerebral hemorrhage may precipitate recurrent bleeding.
Hypertensive intracerebral haemorrhage is usually a once in a lifetime event and recurrences are rare. Most recurrences usually develop within 2 years of the first event and the majority usually target the basal ganglia and thalami. Failure of blood pressure control is the most important, potentially preventable, culprit behind the development of primary intracerebral haemorrhages. However, the occurrence of a recurrent bleed in patients with optimally controlled hypertension should always prompt the physician to think of a new co-operating factor. We report on a 60-year-old hypertensive woman who developed right-sided thalamic haemorrhage 5 days after sustaining a lacunar infarct of the left thalamus for which she had been prescribed a dual antiplatelet therapy: aspirin and clopidrogrel. She had a history of two bilateral sequential hypertensive deep cerebellar haemorrhages which were developed 2 years ago.
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Osama Shukir Muhammed Amin (2012) conducted a case report in Recurrent hypertensive intracerebral haemorrhage (n=1). Dual antiplatelet therapy (aspirin and clopidogrel) was evaluated on Right-sided thalamic haemorrhage. A 60-year-old hypertensive woman developed a right-sided thalamic haemorrhage 5 days after starting dual antiplatelet therapy for a lacunar infarct, despite optimally controlled hypertension.
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