Key result
Cell-derived microparticles, particularly of endothelial and platelet origin, are implicated in the pathophysiology, diagnosis, and prognosis of cardiovascular diseases including atherosclerosis.
Why the study?
Circulating microparticles have been linked to cardiovascular disease, motivating research into their role as biomarkers for diagnosis, prognosis, and disease monitoring.
Cell-derived microparticles, particularly of platelet and endothelial origin, show promise as biomarkers for cardiovascular disease progression, including atherosclerosis, acute coronary syndromes, and heart failure.
Supports biomarker exploration in atherosclerosis and heart failure; leaves open prospective validation before clinical adoption.
Cardiovascular disease remains the main cause of human morbidity and mortality in developed countries. Microparticles (MPs) are small vesicles originating from the cell membrane as a result of various stimuli and particularly of biological processes that constitute the pathophysiology of atherosclerosis, such as endothelial damage. They form vesicles that can transfer various molecules and signals to remote target cells without direct cell-to-cell interaction. Circulating microparticles have been associated with cardiovascular diseases. Therefore, many studies have been designed to further investigate the role of microparticles as biomarkers for diagnosis, prognosis, and disease monitoring. To this concept, the pro-thrombotic and atherogenic potential of platelets and endothelial-derived MPs have gained research interest, especially concerning accelerated atherosclerosis and triggering as well as prognosis of an acute coronary syndrome. MPs, especially those of endothelial origin, have been investigated in different clinical scenarios of heart failure and in association with left ventricular loading conditions. Finally, most cardiovascular risk factors present unique features in the circulating MPs population, highlighting their pathophysiologic link to cardiovascular disease progression. In this review article, we present a synopsis of the biogenesis and characteristics of microparticles, as well as the most recent data concerning their implication in cardiovascular settings.
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Stampouloglou et al. (2022) conducted a review in Cardiovascular diseases. Cell-derived microparticles was evaluated. Cell-derived microparticles, particularly of endothelial and platelet origin, are implicated in the pathophysiology, diagnosis, and prognosis of cardiovascular diseases including atherosclerosis.
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