Key result
Current use of codeine or propoxyphene in adults aged 65 or older was associated with an increased risk of hip fracture compared to nonusers (RR 1.6; 95% CI 1.4-1.9).
Why the study?
Does the use of codeine or propoxyphene increase the risk of hip fracture in elderly persons?
Case-Control (n=28,541)
Does the use of codeine or propoxyphene increase the risk of hip fracture in elderly persons?
Relative Risk: 1.6 (95% CI 1.4–1.9)
Current use of codeine or propoxyphene in elderly patients is associated with a significantly increased risk of hip fracture, particularly among new users and those concurrently taking psychotropic medications.
No takes yet. Share an insight, caveat, or question.
Urges caution prescribing codeine or propoxyphene to adults ≥65; leaves open causal confirmation in prospective studies.
Shorr et al. (1992) conducted a case-control in Hip fracture (n=28,541). Codeine or propoxyphene vs. Nonusers was evaluated on Hip fracture (RR 1.6, 95% CI 1.4-1.9). Current use of codeine or propoxyphene in adults aged 65 or older was associated with an increased risk of hip fracture compared to nonusers (RR 1.6; 95% CI 1.4-1.9).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: