May 2, 2013American Journal of EpidemiologyOpen Access

Opioid Use for Noncancer Pain and Risk of Fracture in Adults: A Nested Case-Control Study Using the General Practice Research Database

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Why the study?

Does acute opioid use increase the risk of fracture in adults with noncancer pain?

Structured PICO

Does acute opioid use increase the risk of fracture in adults with noncancer pain?

Population

Adults aged 18-80 years without cancer who received ≥1 opioid prescription during 1990-2008 in the United Kingdom-based General Practice Research Database. Cases had a first diagnosed fracture of the hip, humerus, or wrist; up to 4 controls per case were matched by age, sex, index date, and general practice.

Intervention

Current use of 1 opioid prescription (acute use)

Comparator

Matched controls (implied non-use or different opioid exposure) and current use of >20 opioid prescriptions (chronic use)

Outcome

First diagnosed fracture of the hip, humerus, or wristhard clinical

Acute opioid use is associated with a significantly increased risk of fracture, likely driven by acute central nervous system effects rather than chronic opioid-induced hypogonadism.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May warrant caution with initial opioid prescriptions in noncancer pain; leaves open mechanisms and requires prospective confirmation.

Cite This Study

Li et al. (2013) studied this question.

synapsesocial.com/papers/6a6ff61d31a3df8243284255 https://doi.org/10.1093/aje/kwt013

View Full Paper

Ask AI

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Opioid Use for Noncancer Pain and Risk of Fracture in Adults: A Nested Case-Control Study Using the General Practice Research Database

Structured PICO

Discussion

Implication

Cite This Study

Opioid Use for Noncancer Pain and Risk of Fracture in Adults: A Nested Case-Control Study Using the General Practice Research Database

Structured PICO

Discussion

Implication

Cite This Study

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