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June 5, 2026The Lancet MicrobeOpen Access

Regional and temporal trends in antimicrobial susceptibility among isolates from bacterial keratitis: a systematic review and meta-analysis

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Authors

STStephen TuftMoorfields Eye Hospital NHS Foundation TrustETElliott H TaylorLondon School of Hygiene & Tropical MedicineKMKeri McLeanUniversity of Liverpool

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Implication

Systematic review assesses antimicrobial resistance in bacterial keratitis isolates, highlighting regional differences and implications for therapy.

Key Points

  • The aim is to identify regional and temporal differences in antimicrobial resistance influencing empirical therapy choices for bacterial keratitis.
  • Conducted a systematic review and meta-analysis across multiple databases until October 2025.
  • Included data from 340 reports on bacterial isolates from eyes with keratitis, totaling 129,388 cases.
  • Used random-effects meta-analysis to summarize proportions of susceptible isolates by region and time.
  • Susceptibility of coagulase-positive Staphylococcus spp to ciprofloxacin was 70.8% in South Asia vs 86.9% in high-income countries.
  • Pseudomonas spp susceptibility to ciprofloxacin was 80.2% in South Asia compared to 98.3% in high-income countries.
  • No evidence of reduced susceptibility over time for any drug-pathogen combination was found.

Cite This Study

Tuft et al. (2026) studied this question.

synapsesocial.com/papers/6a22672f763171746d545ea4https://doi.org/10.1016/j.lanmic.2026.101359
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