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Investigates the impact of noncoordinating chloro groups on selectivity in reactions using imines and alkynes, suggesting new pathways for product formation.
Noncoordinating halogen groups in unsymmetric alkynes were found to have a novel function that can regulate regioselectivity and chemoselectivity in the Rh-catalyzed C-H active annulation of imines and alkynes. It provided up to single-regioisomeric level selectivity for ketimines. It is noteworthy that, for acyclic aldimines, it could not only give excellent control of regioselectivity but also control of chemoselectivity by affording addition products rather than imine products via dehydrogenation.
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Yang et al. (2026) studied this question.
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