Key result
Concomitant vasospastic angina linked to acute progression and recurrence of SCAD lesions.
Why the study?
Spontaneous coronary artery dissection is a rare cause of acute myocardial infarction with unclear pathophysiological mechanisms, though coronary vasospasm has been proposed as a possible triggering factor.
Case Report (n=1)
Answers are grounded in this paper and cite their sources.
Concomitant vasospastic angina may be associated with acute progression or recurrence of spontaneous coronary artery dissection.
Background Spontaneous coronary artery dissection (SCAD) is a rare cause of acute myocardial infarction (AMI). Although the exact pathophysiological mechanism of SCAD remains unclear, coronary vasospasm has been proposed as a possible associated or triggering factor. Case summary A 39-year-old woman presented with sudden-onset back pain and ST-segment elevation in leads V1–V6 on electrocardiogram. Emergent coronary angiography (CAG) revealed subtotal occlusion with dissection in the mid left anterior descending artery (LAD), and intravascular ultrasound demonstrated that dissection extended from the mid portion to the ostium of the LAD. We deployed drug-eluting stent for the mid LAD and confirmed re-perfusion. After the PCI, she developed recurrent chest pain with transient ST-segment elevation in the inferior leads. Emergent CAG demonstrated diffuse severe stenosis in the distal right coronary artery. Both symptoms and electrocardiographic changes resolved spontaneously, coronary vasospasm was considered the most likely cause. On day 17, follow-up CAG revealed progression of stenosis from mild to severe in the mid to ostial LAD and a new dissecting lesion in the mid right coronary artery. Repeat PCI was performed, and the patient remained stable after discharge. Discussion There are some SCAD cases that present acute progression or recurrence. The prognostic factor was unknown, while this case would suggest that vasospasm angina pectoris (VSA) might be associated with those events. Consideration of concomitant VSA may be warranted in the clinical management of patients with SCAD.
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Oda et al. (2026) conducted a case report in Spontaneous coronary artery dissection (SCAD) and vasospastic angina (n=1). Vasospastic angina (VSA) was evaluated. In a 39-year-old woman with spontaneous coronary artery dissection, concomitant vasospastic angina was associated with acute progression and recurrence of dissecting lesions.
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