Comparative Evaluation of the Efficacy of Biologically-based Regenerative Endodontic Procedures in the Healing of Periapically Involved Young, Immature Permanent Teeth With/Without Using Mineral Trioxide Aggregate

IntroductIonApexification using biomimetic materials and procedure and cell-free regenerative therapy (CFRET) using blood clot are two established options for treating the immature nonvital tooth with apical periodontitis. 1 The clinical method for apexification involves either creating an artificial barrier at the apex or inducing an apical closure.Tricalcium silicate cement is the preferred material because of its biocompatibility and sealing properties. [2]3][4][5][6] Biologically based techniques intended to restore damaged materials, such as dentin and pulp-dentin complex cells, can be characterized as the new idea of regenerative endodontic procedures. 7,8Achieving a bacteria-tight seal coronally to prevent bacterial invasion into the pulp space before revascularization can occur is crucial to the procedure's effectiveness. [2][][4][5][6][7][8][9][10] The present study aimed to evaluate the ef ficacy of biologically based regenerative endodontic procedures in healing periapically involved young immature permanent teeth in children.