Why the study?
Does Angiotensin-(1-7) induce vasodilation in canine coronary arteries?
Population
Intact canine coronary artery rings precontracted with the thromboxane A2 analogue U46,619
Comparison
Angiotensin-(1-7) vs Pretreatment with various inhibitors and…
Design
Preclinical
Authors
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Cannot yet guide hypertension therapy; leaves open Ang-(1-7) coronary effects for human investigation.
Does Angiotensin-(1-7) induce vasodilation in canine coronary arteries?
Ang-(1-7) elicits coronary vasodilation mediated by the endothelium-dependent release of nitric oxide, involving a B2 bradykinin receptor and a non-AT1, non-AT2 angiotensin receptor.
Brosnihan et al. (1996) studied this question.
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