Population
Intact canine coronary artery rings suspended in organ chambers
Comparison
Angiotensin- [Ang-] at various concentrations vs Vehicle
Design
Preclinical
Authors
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May enhance coronary kinin signaling in animals; leaves open translation to human hypertension therapy.
Ang-(1-7) acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting angiotensin converting enzyme and releasing nitric oxide.
Li et al. (1997) studied this question.
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