Key result
Topical application of angiotensin-(1-7) and angiotensin II both modestly increased pial arteriolar diameter in newborn pigs, an effect abolished by indomethacin.
Why the study?
Does angiotensin-(1-7) compared to angiotensin II alter cerebral arteriolar diameter in newborn pigs?
Does angiotensin-(1-7) compared to angiotensin II alter cerebral arteriolar diameter in newborn pigs?
Absolute Event Rate: 17.5% vs 11.3%
p-value: p=<.05
Angiotensin-(1-7) and angiotensin II both act as modest dilators in the cerebral circulation of newborn pigs, with effects likely mediated by prostaglandins.
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Does not support clinical translation to human neonates; hypothesis-generating for prostaglandin-mediated angiotensin effects in neonatal cerebral vessels.
Meng et al. (1993) studied Cerebral circulation regulation (n=17). Angiotensin-(1-7) vs. Angiotensin II was evaluated on Cerebral arteriolar diameter change (p=<.05). Topical application of angiotensin-(1-7) and angiotensin II both modestly increased pial arteriolar diameter in newborn pigs, an effect abolished by indomethacin.
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