Key result
A totally inactive zymogenic precursor of renin (MW 50,000) was identified in hog brain tissues, which is distinct from active big renin.
Population
Hog brain tissues (pituitary, pineal, and other regions)
Design
Preclinical
Authors
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Animal data on hog brain renin zymogen warrant no clinical action; leaves open existence and roles of similar precursors in humans.
Demonstrates that inactive renin zymogen in hog brain is a distinct precursor rather than a complex of active renin and a binding protein.
Hirose et al. (1981) studied this question. Pepstatin-Sepharose column and thiol-blocking reagents was evaluated on Identification and isolation of inactive renin zymogen. A totally inactive zymogenic precursor of renin (MW 50,000) was identified in hog brain tissues, which is distinct from active big renin.