Key result
Homogeneous hog renin and partially purified human kidney renin activated inactive human plasma renin in vitro, decreasing its apparent molecular weight from 54,000 to 38,000 daltons.
Population
In vitro biochemical model using inactive renin prepared from normal human plasma.
Comparison
Incubation with active renin at 37°C for 10 min. vs Control reaction without inactive renin, or…
Design
Preclinical
Authors
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Active renin activates inactive plasma renin in vitro; hypothesis-generating with no current clinical implications.
Absolute Event Rate: 184% vs 6%
Active renin can activate inactive human plasma renin in vitro, resulting in an active enzyme with kinetic properties and molecular weight identical to human kidney renin.
Kokubo et al. (1982) studied this question. Homogeneous hog renin and partially purified human kidney renin vs. Control reaction without inactive renin sample was evaluated on Activation of inactive human plasma renin (renin activity in ng ANG I/mg/h). Homogeneous hog renin and partially purified human kidney renin activated inactive human plasma renin in vitro, decreasing its apparent molecular weight from 54,000 to 38,000 daltons.
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