Key result
Eighty-two cardiac-expressed proteins share at least 80% amino acid sequence homology across humans and six animal models, supporting their translational value in heart failure proteomics research.
This review highlights the utility of proteomics across various animal models to elucidate cellular phenotypes and identify biomarkers and drug targets for heart failure.
Supports cross-species HF proteomics; leaves open which proteins merit clinical validation.
Cardiovascular disease is the leading cause of death in the western world. Heart failure is a heterogeneous and complex syndrome, arising from various etiologies, which result in cellular phenotypes that vary from patient to patient. The ability to utilize genetic manipulation and biochemical experimentation in animal models has made them indispensable in the study of this chronic condition. Similarly, proteomics has been helpful for elucidating complicated cellular and molecular phenotypes and has the potential to identify circulating biomarkers and drug targets for therapeutic intervention. In this review, the use of human samples and animal model systems (pig, dog, rat, mouse, zebrafish, and fruit fly) in cardiac research is discussed. Additionally, the protein sequence homology between these species and the extent of conservation at the level of the phospho-proteome in major kinase signaling cascades involved in heart failure are investigated.
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Kooij et al. (2014) conducted a review in Heart failure. Animal models in proteomics was evaluated. Eighty-two cardiac-expressed proteins share at least 80% amino acid sequence homology across humans and six animal models, supporting their translational value in heart failure proteomics research.
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