Solid Pseudopapillary Tumor of the Pancreas: Contemporary Diagnostic and Therapeutic Approaches with Single-Center Experience

Aims Solid pseudopapillary tumor (SPT) is a rare pancreatic disease with unclear oncogenesis and increasing incidence; therefore, it deserves the attention of the professional community. This study reports the results of patients with SPT in a single-center experience using minimally invasive surgical approaches and evaluates the current management of SPT through a comprehensive literature review. Methods Retrospective analysis of all consecutive patients with SPT who underwent surgical treatment between 2020 and 2024 at a single center with follow-up observation. Results From 2020 to 2024, a total of 165 pancreatic resections were performed in a single center, among them, 8 SPT patients were included (15–52 years of age). 5 SPT patients underwent pancreaticoduodenectomy (PD), four cases by laparoscopic approach. 3 SPT patients underwent laparoscopic distal pancreatectomy (DP), two of whom underwent a spleen-preserving procedure. No recurrence of SPT was observed in the study cohort, as confirmed by follow-up imaging. Conclusion It predominantly affects a younger demographic, with a female preponderance. Minimally invasive radical surgical intervention is the preferred therapeutic approach. Even when synchronous metastasectomy is indicated, extensive lymphadenectomy is not required. Due to its low malignant potential and the risk of metastasis being limited to approximately 15% of cases, the 5-year survival rate is excellent.