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June 5, 2026The Pediatric Infectious Disease Journal0 citations

Invasive Pneumococcal Disease Trends in Argentine Children Post-PCV13 Implementation

Invasive Pneumococcal Disease in Argentine Children After Widespread PCV13 Use: Burden, Potential PCV20 Coverage and Mortality Risk Factors Across Three Years of Surveillance

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Authors

ÁGÁngela GentileJBJulia BakirSPSantiago López Papucci

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Overview

Observational study evaluates IPD burden and PCV20 coverage in children, highlighting severe clinical outcomes and mortality factors.

Key Points

  • Assess the burden of invasive pneumococcal disease (IPD) and identify mortality risk factors in Argentine children post-PCV13 implementation.
  • Multicenter prospective observational study in 6 pediatric hospitals
  • Active surveillance of children ≤15 years with laboratory-confirmed IPD
  • Data collection from October 2022 to September 2025
  • 218 cases of IPD identified from 136,018 hospital discharges, with a rate of 16.0 per 10,000 (95% CI, 14.0-18.3)
  • Estimated PCV20 coverage of 51.3% with 30.3% of isolates being PCV13
  • Mortality rate of 5.0%; sepsis and meningitis were significant risk factors (aOR 20.82 and aOR 10.75, respectively)
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Cite This Study

Gentile et al. (2026) studied this question.

synapsesocial.com/papers/6a2269c9763171746d54869chttps://doi.org/10.1097/inf.0000000000005299
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