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January 14, 2026Open Forum Infectious DiseasesOpen Access

Impact of PCV13 introduction on the evolution of multidrug resistance (MDR) in S. pneumoniae causing invasive pneumococcal disease (IPD) in Argentina

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Authors

PGPaula GagettiJZJonathan C ZintgraffNENahuel Sanchez Eluchans

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Overview

Surveillance reveals rising multidrug resistance in invasive pneumococcal disease post-PCV13 in Argentina, indicating significant clonal shifts.

Key Points

  • To evaluate the evolution of multidrug resistance in S. pneumoniae after the introduction of PCV13 in Argentina.
  • Analyzed 1582 IPD isolates from hospitals across 24 jurisdictions in Argentina.
  • Conducted serotyping via Quellung and MIC testing by agar dilution.
  • Examined specific serotypes using whole genome sequencing (WGS) for deeper insights.
  • 344 of the 1582 isolates (21.7%) were identified as multidrug resistant (MDR).
  • MDR increased from 17% in 2013-14 to 23% in 2023-24, associated with specific resistance patterns.
  • Notable increases in non-vaccine serotypes (24F/A/B) driving MDR trends despite decreases in certain vaccine serotypes.

Cite This Study

Gagetti et al. (2026) studied this question.

synapsesocial.com/papers/6966f30613bf7a6f02c0090ehttps://doi.org/10.1093/ofid/ofaf695.115
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