Key result
Insulin resistance, but not hyperinsulinemia, stimulates hepatic VLDL production, driving atherogenic diabetic dyslipidemia characterized by increased small dense LDL and decreased HDL2 cholesterol.
Design
Review
Authors
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May inform diabetic dyslipidemia management via insulin sensitization; leaves open prospective outcome trials.
This review highlights that insulin resistance drives diabetic dyslipidemia by stimulating hepatic VLDL1 overproduction, leading to increased atherogenic small dense LDL and decreased protective HDL2.
Tsutomu Hirano (2018) conducted a review in Diabetic Dyslipidemia. Insulin resistance was evaluated. Insulin resistance, but not hyperinsulinemia, stimulates hepatic VLDL production, driving atherogenic diabetic dyslipidemia characterized by increased small dense LDL and decreased HDL2 cholesterol.
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