Chylomicron-Derived Fatty Acid Spillover in Adipose Tissue: A Signature of Metabolic Health?
Key result
Chylomicron-derived fatty acid spillover was higher in individuals with BMI <25 kg/m2 vs ≥25 kg/m2 (22.2% vs 18.6%, P=0.02) and in women vs men (21.9% vs 15.0%, P=0.001).
Why the study?
Does adiposity or sex affect the proportion of chylomicron-derived fatty acid spillover into the systemic NEFA pool in healthy individuals?
Population
71 healthy men and women across a range of adiposity. A substudy included 6 men and 6 women.
Comparison
Mixed meal (40 g fat) containing [U13C]palmitate vs Comparisons between BMI <25 kg/m2 vs BMI ≥25…
Design
Cross-sectional
Follow-up
postprandial state
Authors
Discussion
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Implication
Higher spillover in lean individuals and women supports normal physiology; hypothesis-generating for its role in obesity-related NEFA excess.
Study Design
Type
Cross-Sectional (n=71)
Structured PICO
Does adiposity or sex affect the proportion of chylomicron-derived fatty acid spillover into the systemic NEFA pool in healthy individuals?
P
Population
71 healthy men and women assessed for chylomicron-derived fatty acid spillover in the postprandial state.
E
Exposure
Mixed meal (40 g fat) containing [U13C]palmitate
C
Comparator
Comparisons between BMI <25 kg/m2 vs BMI ≥25 kg/m2, and women vs men
O
Outcome
Proportion of chylomicron-derived spillover fatty acids into the plasma nonesterified fatty acid (NEFA) poolsurrogate
Main Result
Absolute Event Rate: 22.2% vs 18.6%
p-value: p=0.02
Chylomicron-derived fatty acid spillover is greater in lean individuals and women, suggesting it is a normal physiological process rather than a driver of obesity-related excess NEFA.
Cite This Study
Piché et al. (2017) conducted a cross-sectional in Healthy (n=71). BMI <25 kg/m2 vs. BMI ≥25 kg/m2 was evaluated on Chylomicron-derived FA spillover (p=0.02). Chylomicron-derived fatty acid spillover was higher in individuals with BMI <25 kg/m2 vs ≥25 kg/m2 (22.2% vs 18.6%, P=0.02) and in women vs men (21.9% vs 15.0%, P=0.001).