Efficacy and Safety of Milrinone in Preventing Low Cardiac Output Syndrome in Infants and Children After Corrective Surgery for Congenital Heart Disease

238 neonates and young children at high risk for developing low cardiac output syndrome (LCOS) after corrective surgery for congenital heart disease

Prophylactic milrinone (low dose: 25-μg/kg bolus over 60 minutes followed by 0.25-μg/kg per min infusion for 35 hours; high dose: 75-μg/kg bolus followed by 0.75-μg/kg per min infusion for 35 hours)

Placebo

Composite end point of death or the development of LCOS evaluated at 36 hours and up to 30 days after randomizationcomposite