This review of the Framingham cohorts highlights the foundational role of traditional risk factors in the development of coronary heart disease over a 40-year follow-up.
Supports traditional risk factor focus in practice; leaves open contemporary relevance beyond Framingham cohorts.
Data collected during almost 40 years' follow-up of over 10,000 participants in the Framingham Study and the Framingham Offspring Study are reviewed to highlight the influence of the following factors on the risk for coronary heart disease: systolic blood pressure; lipids (total cholesterol, high-density-lipoprotein low-density-lipoprotein cholesterol, and triglycerides); cigarette smoking; diabetes mellitus; obesity; and left ventricular hypertrophy.
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Bernard E. Kreger (1991) studied this question.
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