May 1, 1989Hypertension327 citationsOpen Access
Blood pressure as a risk factor for cardiovascular disease. The Framingham Study--30 years of follow-up.
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Structured PICO
Does blood pressure predict the development of cardiovascular disease in adults initially free of cardiovascular disease?
P
Population
5,070 men and women aged 30-62 years, free of cardiovascular disease at baseline (Framingham Study cohort)
I
Intervention
Blood pressure (exposure/risk factor)
O
Outcome
Development of coronary heart disease, stroke, transient ischemic attack, and congestive heart failurehard clinical
This landmark 30-year follow-up of the Framingham cohort establishes blood pressure as a strong, independent predictor of major cardiovascular events including coronary heart disease, stroke, and heart failure.
Abstract
Data from 30 years of follow-up of the original Framingham Study cohort of 5,070 men and women aged 30-62 years who were first examined during the period 1948-1952 and who were free of cardiovascular disease reveal that blood pressure is a strong and consistent predictor of the development of coronary heart disease, stroke, transient ischemic attack, and congestive heart failure. Other factors related to blood pressure like obesity, left ventricular hypertrophy as demonstrated on electrocardiograms, and heart enlargement as shown by x-ray radiography made several selective additional independent contributions to risk; heart enlargement by x-ray radiography was the best predictor of congestive heart failure.
Cite This Study
Stokes et al. (1989) studied this question.