The paper discusses the clinical features and mechanisms of accelerated (malignant) primary hypertension, focusing on the potential role of height, weight, and their ratio.
May aid recognition of accelerated hypertension; leaves open the role of anthropometrics and requires prospective validation.
The accelerated ("malignant") form of hypertension is characterized by the presence of pathological changes indicative of a widespread necrotizing arteriolitis. Strong but not certain evidence for this diagnosis may be obtained on clinical grounds, particularly when patients are encountered with established diastolic hypertension, with rapidly progressive renal damage, and usually—although not necessarily—with retinopathy and papilledema. Separation of the accelerated form from other types of hypertension was made by Volhard and Fahr, in 1914.¹Since that time there have been numerous descriptions of its clinical features and its rather uniform rapidly downhill course.²⁻⁵It is accepted generally that this condition occurs infrequentlyde novo, appearing more often after the previous development of primary (essential) or secondary hypertension. Discussion continues as to whether one is dealing with a phase dependent solely upon the intensity of the hypertensive process or whether a superimposed and qualitatively different mechanism is responsible.⁶The
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George A. Perera (1957) studied this question.
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