Key result
There is a large 9-AC-sensitive Cl- conductance in the T-system of rat skeletal muscle fibres, and a smaller, relatively 9-AC-insensitive Cl- conductance in toad fibres.
The study identifies a significant 9-AC-sensitive chloride conductance in the T-system of rat skeletal muscle fibers, providing insights into the basis of chloride channel aberrations in myotonia.
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No immediate clinical implications for myotonia; leaves open translational relevance of species-specific T-system Cl- conductances.
Coonan et al. (1998) studied this question. Chloride and 9-anthracene carboxylic acid (9-AC) was evaluated on T-system depolarization and Ca2+ release. There is a large 9-AC-sensitive Cl- conductance in the T-system of rat skeletal muscle fibres, and a smaller, relatively 9-AC-insensitive Cl- conductance in toad fibres.
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