Key result
In skinned toad muscle fibres, T-system depolarization tightly controls calcium release, while ryanodine induces prolonged contractions that cannot be stopped by repolarization.
This preclinical study demonstrates that T-system membrane potential tightly controls calcium release from the sarcoplasmic reticulum in toad muscle fibers, a process significantly altered by ryanodine.
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Cannot inform clinical calcium-handling therapies; leaves open T-system control mechanisms in mammalian muscle.
Lamb et al. (1990) studied this question. Ryanodine and T-system depolarization was evaluated on Muscle contraction and calcium release. In skinned toad muscle fibres, T-system depolarization tightly controls calcium release, while ryanodine induces prolonged contractions that cannot be stopped by repolarization.
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