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No immediate clinical implications; leaves open translation of metaraminol neurotransmission to human sympathetic signaling.
Cats were injected intravenously with metaraminol, an amine which depletes norepinephrine from the sympathetic nerve endings; their hearts were then perfused in vitro. Stimulation of the sympathetic nerve supply released metaraminol from the hearts, demonstrating that a synthetic compound can replace norepinephrine and serve as a transmitter at adrenergic nerve endings
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Crout et al. (1964) studied this question.
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