The Conservative Management of Barbiturate Intoxication: Experience With 95 Unconscious Patients

Article1 April 1961THE CONSERVATIVE MANAGEMENT OF BARBITURATE INTOXICATION: EXPERIENCE WITH 95 UNCONSCIOUS PATIENTSMATTHEW J. FERGUSON, M.D., WILLIAM J. GRACE, M.D., F.A.C.P.MATTHEW J. FERGUSON, M.D.Search for more papers by this author, WILLIAM J. GRACE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-4-726 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis paper reports our experience with the management of barbiturate intoxication in 140 patients over a six-year period (1953 to 1959). The patients were seen at St. Vincent's Hospital in the heart of Greenwich Village, New York, where there is an unusually high incidence of barbiturate overdosage. Only those patients who were unconscious or whose sensorium was depressed were admitted to the hospital, and only those who were hospitalized were studied.Forty-five of the 140 cases were omitted from this report because they presented no therapeutic problem (Class O of Reed et al.1); because there was a question of whether...Bibliography1. ReedDriggsFoote CEMFCC: Acute barbiturate intoxication: a study of 300 cases based on a physiological system of classification of severity of intoxication. Ann. Intern. Med. 37: 290, 1952. LinkGoogle Scholar2. Kjaer-Larsen J: Delirious psychosis and convulsions due to Megimide. Lancet 271 (2): 967, 1956. CrossrefMedlineGoogle Scholar3. Nilsson E: On the treatment of barbiturate poisoning; modified clinical aspects. Acta Med. Scand., Supp. 252-256, Vol. 1, 1951. Google Scholar4. Kopanyi T: Acute barbiturate intoxication. J. Forensic Med. 4: 65, 1957. Google Scholar5. EkenhoffDam JEW: The treatment of barbiturate poisoning with or without analeptics. Amer. J. Med. 20: 912, 1956. CrossrefMedlineGoogle Scholar6. LeavensonPlumSwanson GSFAG: Physiological management compared with pharmacological and electrical stimulation in barbiturate poisoning. J. Pharmacol. Exp. Ther. 122: 271-280, 1958. MedlineGoogle Scholar7. PlumSwanson FAG: Barbiturate poisoning treated by physiological methods. J. A. M. A. 163: 827, 1957. CrossrefMedlineGoogle Scholar8. ShawSimonCassShulmanAnsteeNelson FHSENAJRER: Barbiturate antagonism. Nature (Lond.) 174: 402, 1954. CrossrefMedlineGoogle Scholar9. Madsen K: Daptazole and Megimide in the treatment of acute barbiturate intoxication. T. Norske Laegeforen. 77: 60, 1957. MedlineGoogle Scholar10. HarstadMølierSimesen EKOMH: Uber den wert der magenspulung bei der behandlung von akuten Vergiftungen. Acta Med. Scand. 112: 478-514, 1942. CrossrefGoogle Scholar11. Wright JT: The value of barbiturate estimations in the diagnosis and treatment of barbiturate intoxication. Quart. J. Med. 24: 95, 1955. MedlineGoogle Scholar12. Louw A: Ten years' experience at the Center for the Treatment of Poisoning in Copenhagen. Danish Med. Bull. 5: 137, 1958. MedlineGoogle Scholar13. PetersdorfCurtinHoeprichPeelerBennett RGJAPDRNIL: A study of antibiotic prophylaxis in unconscious patients. New Engl. J. Med. 257: 1001, 1957. CrossrefMedlineGoogle Scholar14. Weinstein L: Chemoprophylaxis of infection. Ann. Intern. Med. 43: 287, 1955. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication October 13, 1959.From the Department of Medicine, The St. Vincent's Hospital of the City of New York, and the New York University College of Medicine, New York, N. Y.Requests for reprints should be addressed to Matthew J. Ferguson, M.D., The St. Vincent's Hospital of the City of New York, 153 W. 11th Street, New York 11, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByExtracorporeal Treatment for Barbiturate Poisoning: Recommendations From the EXTRIP WorkgroupEnhanced elimination in acute barbiturate poisoning – A systematic reviewCan one Predict Outcome of Medical Coma?Hemoperfusion to Treat IntoxicationsJONATHAN A. LORCH, M.D., SERAFINO GARELLA, M.D.The management of drug overdosageSevere Drug Overdose: Results of TreatmentEARLY TREATMENT OF THE UNCONSCIOUS PATIENT SUFFERING FROM DRUG OVERDOSETreatment of Barbiturate Intoxication With a Report of Recent Experience at Peter Bent Brigham HospitalLEE W. HENDERSON, M.D., JOHN P. MERRILL, M.D.Limited Usefulness of Alkaline Diuresis and Peritoneal Dialysis in Pentobarbital IntoxicationBARBITURATE POISONING 1 April 1961Volume 54, Issue 4Page: 726-733KeywordsComaHeartHospital medicineIntoxicationIntubationPneumonia Issue Published: 1 April 1961 PDF DownloadLoading ...