Cardiac Sympathetic Dysautonomia in Chronic Orthostatic Intolerance Syndromes
Why the study?
Does cardiac sympathetic innervation or function differ in patients with POTS or NCS compared to healthy volunteers?
Population
88 participants, including patients with postural tachycardia syndrome, repeated neurocardiogenic…
Comparison
Measurement of neurochemical indices of cardiac… vs Healthy volunteers and a subgroup of age-matched…
Design
Cross-sectional
Authors
Discussion
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Implication
Supports distinct sympathetic phenotypes in POTS and NCS; leaves open whether spillover measurements guide therapy.
Structured PICO
Does cardiac sympathetic innervation or function differ in patients with POTS or NCS compared to healthy volunteers?
P
Population
88 participants, including patients with postural tachycardia syndrome (POTS, N=16), repeated neurocardiogenic presyncope (NCS, N=20), and healthy volunteers (N=52, including a subgroup of 11 age-matched healthy women).
I
Intervention
Measurement of neurochemical indices of cardiac norepinephrine release, reuptake, and synthesis, and left ventricular myocardial innervation density using 6-[(18)F]fluorodopamine PET scanning.
C
Comparator
Healthy volunteers (N=52) and a subgroup of age-matched healthy women (N=11).
O
Outcome
Cardiac norepinephrine spillover, cardiac extraction of circulating (3)H-norepinephrine, cardiac production of dihydroxyphenylalanine, and myocardial 6-[(18)F]fluorodopamine-derived radioactivity.surrogate
POTS and NCS exhibit distinct abnormalities in tonic cardiac sympathetic function, with increased norepinephrine release in POTS and decreased release in NCS, supporting their classification as forms of dysautonomia.
Cite This Study
Goldstein et al. (2002) studied this question.