Key result
Coronary arterial disease was the strongest independent risk factor for elevated cardiac troponin T levels (OR 25.2) in pre-dialysis chronic kidney disease patients, alongside smoking, low eGFR, and arterial stiffness.
Why the study?
Although cardiac troponin T is independently associated with cardiovascular complications in chronic kidney disease patients, the factors related to cTnT levels in pre-dialysis CKD patients that lead to increased cardiovascular risk remained to be determined.
What factors are independently associated with elevated high-sensitivity cardiac troponin T levels in pre-dialysis chronic kidney disease patients?
Cross-Sectional (n=147)
No
What factors are independently associated with elevated high-sensitivity cardiac troponin T levels in pre-dialysis chronic kidney disease patients?
In pre-dialysis CKD patients, elevated high-sensitivity cardiac troponin T is independently associated with coronary artery disease, arterial stiffness, smoking, primary renal disease, and lower eGFR.
Supports CAD evaluation in pre-dialysis CKD with troponin elevation; hypothesis-generating and should not change practice yet.
Cardiac troponin T (cTnT) is independently associated with cardiovascular complications in patients with chronic kidney disease (CKD). The present study aimed to determine the factors related to cTnT levels in pre-dialysis CKD patients, which result to increased cardiovascular risk.
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Raikou et al. (2022) conducted a cross-sectional in Pre-dialysis Chronic Kidney Disease (n=147). Coronary arterial disease vs. No coronary arterial disease was evaluated on Elevated cardiac troponin T (>14 ng/L) (OR 25.2, 95% CI 5.6-113.6, p=0.001). Coronary arterial disease was the strongest independent risk factor for elevated cardiac troponin T levels (OR 25.2) in pre-dialysis chronic kidney disease patients, alongside smoking, low eGFR, and arterial stiffness.
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