Key result
Pulmonary artery acceleration time showed a significant positive correlation with left ventricular diastolic function parameters, including lateral e' (SCC 0.47), in women but not in men.
Why the study?
PAAT evaluates pulmonary hypertension and aids LVDF analyses, but its correlation with LVDF parameters across sex, age, and cardiovascular risk factors in preserved LV systolic function requires assessment.
Does pulmonary artery acceleration time (PAAT) correlate with left ventricular diastolic function parameters in individuals with preserved left ventricular systolic function?
Cross-Sectional (n=119)
No
Does pulmonary artery acceleration time (PAAT) correlate with left ventricular diastolic function parameters in individuals with preserved left ventricular systolic function?
Pulmonary artery acceleration time (PAAT) correlates with early signs of left ventricular diastolic dysfunction in women with preserved ejection fraction, suggesting its potential utility as an adjunctive echocardiographic parameter.
PAAT may associate with early diastolic changes in women; hypothesis-generating and requires prospective validation before clinical adoption.
Background: Pulmonary artery acceleration time (PAAT) can be used as a parameter in the evaluation of pulmonary hypertension and aids left ventricular diastolic function (LVDF) analyses. Objective: To assess whether there is a correlation between PAAT and LVDF parameters in individuals with a preserved left ventricular systolic function and by sex, age, and cardiovascular risk factors. Method: Observational cross-sectional study. One hundred nineteen patients were selected (59 women [49.6%]). The subjects underwent transthoracic echocardiography including measurements of PAAT, E and A waves and E/A ratio, e’ septal and e’ lateral waves and E/e’ ratio, pulmonary artery systolic pressure (PASP), and left atrial volume. Results: In female patients, a positive correlation (Spearman’s correlation coefficient – Spearman correlation coefficient [SCC]) was found between the PAAT value and the lateral e’ (SCC, 0.47; p = 0.002), with the E/A ratio (SCC, 0.32; p = 0.04), and with septal e’ (SCC, 0.36; p = 0.023), and a negative correlation between PAAT and PASP (SCC, -0.43; p = 0.034). In men, no correlation was found between PAAT and any parameters. Lower PAAT values were found in women with systemic arterial hypertension (hypertension) than in women without hypertension (0.13 ± 0.03 s versus 0.16 ± 0.03 s; p = 0.015). Conclusion: The present study showed a significant correlation between PAAT and some LVDF parameters in female patients only. Hypertension was correlated with lower PAAT values in women.
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Coimbra et al. (2022) conducted a cross-sectional in Preserved left ventricular systolic function (n=119). Pulmonary artery acceleration time (PAAT) was evaluated on Correlation between PAAT and lateral e' wave in women (SCC 0.47, p=0.002). Pulmonary artery acceleration time showed a significant positive correlation with left ventricular diastolic function parameters, including lateral e' (SCC 0.47), in women but not in men.
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