Key result
In patients with recently diagnosed essential hypertension, obesity was the most important modifiable risk factor for left ventricular hypertrophy, correlating with left ventricular mass (r2=0.167).
Observational (n=1,518)
In patients with recently diagnosed essential hypertension, obesity is the most important modifiable cardiovascular risk factor for developing left ventricular hypertrophy.
OBJECTIVE: Development of left ventricular hypertrophy (LVH) is a multifactorial phenomenon. We retrospectively assessed the risk factors for LVH in patients with recent diagnosis of essential hypertension. METHODS: We analysed 1518 participants with recent diagnosis of essential hypertension (≤2 years). The duration of hypertension was established after cross-checking the patients' history and the records of the general practitioners'. The following cardiovascular (CV) risk factors were considered: age (men >55 years, women >65 years), SBP >140 mmHg, DBP >90 mmHg, obesity, diabetes, hypercholesterolemia, low or high-density lipoprotein (HDL)-cholesterol (men <40 m/dl, women <50 mg/dl), and chronic kidney disease (CKD). RESULTS: Age, prevalence of metabolic diseases, CKD, and the severity of hypertension were higher in patients with LVH. One hundred twenty-two (8%) patients did not have CV risk factors, whereas 288 (19%), 472 (31.1%), 351 (23.1%) and 285 (18.8%) patients had one, two, three and more than three CV risk factors, respectively. At univariate analysis, CV risk factors for LVH where found to be sex, age, SBP, low HDL-cholesterol, obesity, diabetes, CKD, and metabolic syndrome. In the multivariate analysis, the independent predictors of LVH were found to be sex, age, SBP, obesity and diabetes. A significant correlation was found between indexed left ventricular mass and body mass index (r(2) = 0.167), age (r(2) = 0.077) and SBP (r (2)= 0.055). CONCLUSION: This study reveals that, in patients with recent diagnosis of essential hypertension obesity represents the most important modifiable CV risk factor for LVH.
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Buono et al. (2013) conducted an observational in Essential hypertension (n=1,518). Cardiovascular risk factors (obesity, diabetes, SBP, age, sex) vs. Absence of risk factors was evaluated on Left ventricular hypertrophy. In patients with recently diagnosed essential hypertension, obesity was the most important modifiable risk factor for left ventricular hypertrophy, correlating with left ventricular mass (r2=0.167).
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